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American Journal of Oral Medicine and Radiology

Volume 7, Issue 2, 2020
Mcmed International
American Journal of Oral Medicine and Radiology
Issn
XXX-XXXX (Print), 2394 - 7721 (Online)
Frequency
bi-annual
Email
editorajomr@mcmed.us
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Abstract
Title
COMPARATIVE ANALYSIS OF MICROEMULSION PROPOFOL AND LONG-CHAIN TRIGLYCERIDE (LCT) PROPOFOL IN ELECTIVE SURGICAL ANAESTHESIA: EFFICACY, SAFETY, AND POSTOPERATIVE RECOVERY
Author
Venkata Ramana Pindi B
Email
keyword
Microemulsion propofol, Long-chain triglyceride propofol, Postoperative nausea, Anaesthesia recovery
Abstract
This paper is a comparison of the effectiveness, safety, and pharmacokinetic characteristics of microemulsion propofol and long-chain triglyceride (LCT) propofol in elective surgery patients under general anaesthesia. Two hundred and thirty patients were randomly divided into two groups of 115 and 115 patients who received microemulsion propofol and LCT propofol respectively. The major outcomes were anaesthesia infusion parameters, postoperative recovery, and occurrence of postoperative nausea and pain and the secondary outcomes were the necessity of rescue drugs. The outcomes revealed that the two formulations were able to deliver comparable parameters of anaesthesia, including equal propofol infusion rates, the total doses as well as rate changes of propofol. Time to loss of consciousness (LOC), time to return of consciousness (ROC), and time to recover orientation (ROO) which are the measures of postoperative recovery were also similar between the two groups. It is noteworthy that, the prevalence and extent of postoperative nausea were a little less in the microemulsion group than in the LCT one. Pain scores regarding postoperative pain were similar in both groups, and the rescue analgesics were in demand. The results indicate that microemulsion propofol is a possible substitute to LCT propofol, which has comparable efficacy in anaesthesia and recovery with a possibility of decreasing the postoperative nausea. These findings should be verified through further research involving a wide range of patients to determine the long-term benefits of using microemulsion propofol.
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