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European journal of molecular biology and biochemistry

Volume 12, Issue 1, 2025
Mcmed International
European journal of molecular biology and biochemistry
Issn
2348 - 2192 (Print), 2348 - 2206 (Online)
Frequency
bi-annual
Email
editorejmbb@mcmed.us
Journal Home page
http://mcmed.us/journal/ejmbb
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Abstract
Title
CS21-MEDIATED ADHESION MECHANISMS IN ENTEROTOXIGENIC ESCHERICHIA COLI: IMPLICATIONS FOR VIRULENCE AND THERAPEUTIC INTERVENTIONS
Author
Dr. Umesh Kumar C
Email
keyword
Enterotoxigenic Escherichia coli, CS21 pili, adhesion, virulence, therapeutic targets, neonatal mouse model.
Abstract
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrheal diseases, particularly in travelers and infants from developing countries. One of its key virulence factors, the CS21 type IV pili, is implicated in intestinal colonization, adhesion, and microcolony formation. However, the exact role of CS21 in ETEC pathogenesis is not fully understood. This study investigates the role of CS21 in mediating adhesion using in vitro models of epithelial cells (IPEC-J2 and IPEC-1) and in vivo neonatal mouse models. Quantitative adhesion assays revealed that CS21-expressing ETEC strains adhered significantly more to epithelial cells compared to CS21-deficient mutants. Additionally, adhesion was inhibited by anti-LngA monoclonal antibodies and neuraminidase treatment. In vivo, CS21- expressing strains exhibited enhanced virulence in neonatal mice, supporting their role in gut colonization and pathogenicity. These findings position CS21 as a crucial virulence factor in ETEC infections, offering potential targets for novel therapeutic strategies aimed at mitigating ETEC-related diseases
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