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American Journal of Biological and Pharmaceutical Research

Volume 11, Issue 1, 2024
Mcmed International
American Journal of Biological and Pharmaceutical Research
Issn
2348 - 2176 (Print), 2348 - 2184 (Online)
Frequency
bi-annual
Email
editorajbpr@mcmed.us
Journal Home page
http://mcmed.us/journal/ajbpr
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Abstract
Title
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF EXTRACT OF Cucurbita maxima –A REVIEW
Author
Pranabesh Sikdar, Waseem. K*, Muniraja. J, Vinod Kumar. D, Sunitha. P, Sudharshini. J
Email
kwaseem.akram95@gmail.com
keyword
Cucurbita maxima, Anticancer activity, Amino acids.
Abstract
Cucurbita maxima is easily available in many parts of world. The creeper is having different medicinal uses. The different parts of the plant is taken by the people in their daily food habbit. The major constituents present in the plant are amino acids, vitamins, minerals, fibres and carbohydrate etc. The plant have different pharmaceutical activity such as anticancer activity, anti-diabetic activity, anti-bacterial activity, cardiotonic activity, anti-diuretic activity. One important approach for the treatment of type 2 diabetes mellitus is by decreasing the postprandial hyperglycemia in effect. This is possible by inhibiting certain carbohydrate hydrolyzing enzyme like α-amylase and α-glucosidase. Articles have reported that the methanolic extract of leaves of C. maxima showed strong antioxidant (DPPH scavenging) and α-amylase inhibition (IC50 125 μg/ml and IC50 2.1 mg/ml), respectively. The anti-diabetic activity is one of the major activity shown by the leaves. The antibacterial activity is also shown by the seeds and fruits. It was observed that the presence of the basic proteins as constituents are responsible for the antibacterial and antifungal activity. The presence of tannins present were mainly polyphenols which are responsible for the anthelmentic and wound healing property.
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